Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 958462..959045 Replicon chromosome
Accession NZ_CP116110
Organism Escherichia coli strain DETEC-P80

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PIC84_RS04675 Protein ID WP_049253269.1
Coordinates 958710..959045 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1V2T5M9
Locus tag PIC84_RS04670 Protein ID WP_000581941.1
Coordinates 958462..958710 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC84_RS04660 (954801) 954801..956102 + 1302 WP_023281448.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
PIC84_RS04665 (956150) 956150..958384 + 2235 WP_000226815.1 GTP pyrophosphokinase -
PIC84_RS04670 (958462) 958462..958710 + 249 WP_000581941.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PIC84_RS04675 (958710) 958710..959045 + 336 WP_049253269.1 endoribonuclease MazF Toxin
PIC84_RS04680 (959116) 959116..959907 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
PIC84_RS04685 (960135) 960135..961772 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
PIC84_RS04690 (961860) 961860..963158 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12197.18 Da        Isoelectric Point: 8.7218

>T268023 WP_049253269.1 NZ_CP116110:958710-959045 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQARHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9385.76 Da        Isoelectric Point: 4.4665

>AT268023 WP_000581941.1 NZ_CP116110:958462-958710 [Escherichia coli]
MIHSSVKRWGNSPAVRIPTTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5M9

References