Detailed information of TA system TA026802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1754488..1754998
• Replicon: chromosome
• Accession: NC_017452
• Organism: Haemophilus influenzae R2846

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0H3PB74
• Locus tag: R2846_RS08495
• Protein ID: WP_005658624.1
• Coordinates: 1754488..1754709 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: R2846_RS08500
• Protein ID: WP_005650837.1
• Coordinates: 1754702..1754998 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2846_RS08480	1750637..1750801	-	165	WP_032823763.1	hypothetical protein	-
R2846_RS08490	1751346..1754381	+	3036	WP_014551122.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
R2846_RS08495	1754488..1754709	+	222	WP_005658624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R2846_RS08500	1754702..1754998	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
R2846_RS08505	1755165..1757081	+	1917	WP_014551124.1	ABC transporter ATP-binding protein	-
R2846_RS08510	1757091..1757639	+	549	WP_014551125.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
R2846_RS08515	1757655..1758206	+	552	WP_014551126.1	Sua5/YciO/YrdC/YwlC family protein	-
R2846_RS08520	1758210..1759016	+	807	WP_014551127.1	shikimate dehydrogenase	-
R2846_RS08525	1759028..1759786	+	759	WP_014551128.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8834.35 Da
• Isoelectric Point: 10.7588

>T26802 WP_005658624.1 NC_017452:1754488-1754709 [Haemophilus influenzae R2846]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTTQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T26802 NC_017452:1754488-1754709 [Haemophilus influenzae R2846]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTACCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT26802 WP_005650837.1 NC_017452:1754702-1754998 [Haemophilus influenzae R2846]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT26802 NC_017452:1754702-1754998 [Haemophilus influenzae R2846]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0H3PB74