Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 169758..170401 Replicon plasmid pDETEC66
Accession NZ_CP116108
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag PIC05_RS25820 Protein ID WP_001034044.1
Coordinates 169985..170401 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag PIC05_RS25815 Protein ID WP_072647566.1
Coordinates 169758..169988 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS25795 (165320) 165320..166009 - 690 WP_001513524.1 RES family NAD+ phosphorylase -
PIC05_RS25800 (166428) 166428..166658 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin -
PIC05_RS25805 (166655) 166655..167071 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin -
PIC05_RS25810 (167233) 167233..169371 - 2139 WP_001513523.1 AAA family ATPase -
PIC05_RS25815 (169758) 169758..169988 + 231 WP_072647566.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIC05_RS25820 (169985) 169985..170401 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC05_RS25825 (170476) 170476..172041 + 1566 WP_001128474.1 AAA family ATPase -
PIC05_RS25830 (172026) 172026..173048 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..194772 194772
- flank IS/Tn - - 173302..173805 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T268014 WP_001034044.1 NZ_CP116108:169985-170401 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8760.95 Da        Isoelectric Point: 4.6437

>AT268014 WP_072647566.1 NZ_CP116108:169758-169988 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKAEPDFMTERKDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure

References