Detailed information of TA system TA026800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1693208..1693812
• Replicon: chromosome
• Accession: NC_017452
• Organism: Haemophilus influenzae R2846

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: R2846_RS08205
• Protein ID: WP_014551096.1
• Coordinates: 1693208..1693516 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: R2846_RS08210
• Protein ID: WP_005692346.1
• Coordinates: 1693516..1693812 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2846_RS08195	1688335..1689633	-	1299	WP_014551094.1	trigger factor	-
R2846_RS08200	1689933..1693151	+	3219	WP_014551095.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
R2846_RS08205	1693208..1693516	-	309	WP_014551096.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
R2846_RS08210	1693516..1693812	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
R2846_RS08215	1693932..1694057	-	126	WP_041174648.1	selenocysteine synthase	-
R2846_RS08220	1694041..1695900	-	1860	WP_014551097.1	selenocysteine-specific translation elongation factor	-
R2846_RS08225	1695897..1697282	-	1386	WP_014551098.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11903.65 Da
• Isoelectric Point: 7.3180

>T26800 WP_014551096.1 NC_017452:c1693516-1693208 [Haemophilus influenzae R2846]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPESYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T26800 NC_017452:c1693516-1693208 [Haemophilus influenzae R2846]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAGCTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT26800 WP_005692346.1 NC_017452:c1693812-1693516 [Haemophilus influenzae R2846]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT26800 NC_017452:c1693812-1693516 [Haemophilus influenzae R2846]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: Q4QMK8