Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4158033..4158865 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name yeeV Uniprot ID A0A836ZBT7
Locus tag PIC05_RS20205 Protein ID WP_001598217.1
Coordinates 4158033..4158407 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PIC05_RS20210 Protein ID WP_001598216.1
Coordinates 4158497..4158865 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS20165 (4153663) 4153663..4154643 + 981 WP_000379695.1 sialate O-acetylesterase -
PIC05_RS20170 (4154651) 4154651..4154755 - 105 Protein_3943 HNH endonuclease -
PIC05_RS20175 (4154855) 4154855..4154998 + 144 Protein_3944 HNH endonuclease -
PIC05_RS20180 (4155766) 4155766..4155915 - 150 Protein_3945 hypothetical protein -
PIC05_RS20185 (4156000) 4156000..4156125 - 126 Protein_3946 hypothetical protein -
PIC05_RS20195 (4157429) 4157429..4157533 - 105 Protein_3948 hypothetical protein -
PIC05_RS20200 (4157545) 4157545..4158036 - 492 WP_001598218.1 DUF5983 family protein -
PIC05_RS20205 (4158033) 4158033..4158407 - 375 WP_001598217.1 TA system toxin CbtA family protein Toxin
PIC05_RS20210 (4158497) 4158497..4158865 - 369 WP_001598216.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PIC05_RS20215 (4158945) 4158945..4159166 - 222 WP_000692303.1 DUF987 domain-containing protein -
PIC05_RS20220 (4159235) 4159235..4159711 - 477 WP_032198294.1 RadC family protein -
PIC05_RS20225 (4159727) 4159727..4160212 - 486 WP_000206667.1 antirestriction protein -
PIC05_RS20230 (4160304) 4160304..4161122 - 819 WP_001598214.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4148624..4192313 43689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13990.98 Da        Isoelectric Point: 7.8045

>T267999 WP_001598217.1 NZ_CP116106:c4158407-4158033 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLGRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.40 Da        Isoelectric Point: 7.3992

>AT267999 WP_001598216.1 NZ_CP116106:c4158865-4158497 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSRGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836ZBT7

Antitoxin

Source ID Structure

References