267997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3591590..3592427 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PIC05_RS17550 Protein ID WP_000227784.1
Coordinates 3591885..3592427 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PIC05_RS17545 Protein ID WP_001297137.1
Coordinates 3591590..3591901 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS17520 (3586610) 3586610..3587557 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
PIC05_RS17525 (3587579) 3587579..3589570 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PIC05_RS17530 (3589560) 3589560..3590174 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PIC05_RS17535 (3590174) 3590174..3590503 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PIC05_RS17540 (3590515) 3590515..3591405 + 891 WP_000971336.1 heme o synthase -
PIC05_RS17545 (3591590) 3591590..3591901 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PIC05_RS17550 (3591885) 3591885..3592427 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PIC05_RS17555 (3592483) 3592483..3593418 - 936 WP_001297127.1 tetratricopeptide repeat protein -
PIC05_RS17560 (3593826) 3593826..3595190 + 1365 WP_001000978.1 MFS transporter -
PIC05_RS17565 (3595318) 3595318..3595809 - 492 WP_001138904.1 nucleotide binding protein YajQ -
PIC05_RS17570 (3595977) 3595977..3596888 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T267997 WP_000227784.1 NZ_CP116106:3591885-3592427 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT267997 WP_001297137.1 NZ_CP116106:3591590-3591901 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References