Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3557512..3558130 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC05_RS17380 Protein ID WP_001291435.1
Coordinates 3557912..3558130 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC05_RS17375 Protein ID WP_000344800.1
Coordinates 3557512..3557886 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS17365 (3552601) 3552601..3553794 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC05_RS17370 (3553817) 3553817..3556966 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC05_RS17375 (3557512) 3557512..3557886 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC05_RS17380 (3557912) 3557912..3558130 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC05_RS17385 (3558302) 3558302..3558853 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIC05_RS17390 (3558969) 3558969..3559439 + 471 WP_000136192.1 YlaC family protein -
PIC05_RS17395 (3559603) 3559603..3561153 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC05_RS17400 (3561195) 3561195..3561548 - 354 WP_000878141.1 DUF1428 family protein -
PIC05_RS17410 (3561927) 3561927..3562238 + 312 WP_000409911.1 MGMT family protein -
PIC05_RS17415 (3562269) 3562269..3562841 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267996 WP_001291435.1 NZ_CP116106:3557912-3558130 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267996 WP_000344800.1 NZ_CP116106:3557512-3557886 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References