Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2528691..2529329 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PIC05_RS12235 Protein ID WP_000813794.1
Coordinates 2529153..2529329 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC05_RS12230 Protein ID WP_001270286.1
Coordinates 2528691..2529107 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS12210 (2523843) 2523843..2524784 - 942 WP_001251315.1 ABC transporter permease -
PIC05_RS12215 (2524785) 2524785..2525798 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
PIC05_RS12220 (2525816) 2525816..2526961 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PIC05_RS12225 (2527206) 2527206..2528612 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
PIC05_RS12230 (2528691) 2528691..2529107 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC05_RS12235 (2529153) 2529153..2529329 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC05_RS12240 (2529551) 2529551..2529781 + 231 WP_000494239.1 YncJ family protein -
PIC05_RS12245 (2529873) 2529873..2531834 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC05_RS12250 (2531907) 2531907..2532443 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PIC05_RS12255 (2532535) 2532535..2533710 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T267995 WP_000813794.1 NZ_CP116106:c2529329-2529153 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT267995 WP_001270286.1 NZ_CP116106:c2529107-2528691 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References