Detailed information of TA system TA026799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1464808..1465342
• Replicon: chromosome
• Accession: NC_017452
• Organism: Haemophilus influenzae R2846

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: R2846_RS07075
• Protein ID: WP_014551013.1
• Coordinates: 1465052..1465342 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E7A5Y2
• Locus tag: R2846_RS07070
• Protein ID: WP_005651514.1
• Coordinates: 1464808..1465062 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2846_RS07030	1459988..1460248	+	261	WP_005663579.1	hypothetical protein	-
R2846_RS07035	1460278..1460643	+	366	WP_005686191.1	endonuclease domain-containing protein	-
R2846_RS07040	1460981..1463047	+	2067	WP_005686190.1	glycine--tRNA ligase subunit beta	-
R2846_RS07050	1463409..1463948	+	540	WP_005659144.1	hypothetical protein	-
R2846_RS07055	1463978..1464286	+	309	WP_005659142.1	P2 family phage major capsid protein	-
R2846_RS07060	1464286..1464510	+	225	WP_005659141.1	hypothetical protein	-
R2846_RS07070	1464808..1465062	+	255	WP_005651514.1	stability protein StbD	Antitoxin
R2846_RS07075	1465052..1465342	+	291	WP_014551013.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R2846_RS09050	1465423..1465632	+	210	WP_074030365.1	hypothetical protein	-
R2846_RS09205	1465802..1465939	+	138	WP_005659136.1	hypothetical protein	-
R2846_RS07080	1466471..1467505	-	1035	WP_005659128.1	DNA polymerase III subunit delta	-
R2846_RS07085	1467505..1468008	-	504	WP_005659127.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11498.41 Da
• Isoelectric Point: 10.6484

>T26799 WP_014551013.1 NC_017452:1465052-1465342 [Haemophilus influenzae R2846]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTSH

Nucleotide

• Length: 291 bp

>T26799 NC_017452:1465052-1465342 [Haemophilus influenzae R2846]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACATCCCACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9419.78 Da
• Isoelectric Point: 4.0737

>AT26799 WP_005651514.1 NC_017452:1464808-1465062 [Haemophilus influenzae R2846]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Nucleotide

• Length: 255 bp

>AT26799 NC_017452:1464808-1465062 [Haemophilus influenzae R2846]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A5C2QYX4