Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1318206..1318831 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PIC05_RS06340 Protein ID WP_000911329.1
Coordinates 1318433..1318831 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PIC05_RS06335 Protein ID WP_000450524.1
Coordinates 1318206..1318433 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS06310 (1314008) 1314008..1314478 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PIC05_RS06315 (1314478) 1314478..1315050 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PIC05_RS06320 (1315196) 1315196..1316074 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PIC05_RS06325 (1316091) 1316091..1317125 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PIC05_RS06330 (1317338) 1317338..1318051 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PIC05_RS06335 (1318206) 1318206..1318433 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC05_RS06340 (1318433) 1318433..1318831 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC05_RS06345 (1318978) 1318978..1319841 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PIC05_RS06350 (1319856) 1319856..1321871 + 2016 WP_000829393.1 tRNA cytosine(34) acetyltransferase TmcA -
PIC05_RS06355 (1321945) 1321945..1322643 + 699 WP_241226720.1 esterase -
PIC05_RS06360 (1322753) 1322753..1322953 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T267989 WP_000911329.1 NZ_CP116106:1318433-1318831 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT267989 WP_000450524.1 NZ_CP116106:1318206-1318433 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References