Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875762..876416 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag PIC05_RS04260 Protein ID WP_000244783.1
Coordinates 876009..876416 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC05_RS04255 Protein ID WP_000354046.1
Coordinates 875762..876028 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS04230 (870931) 870931..871674 + 744 WP_000951948.1 SDR family oxidoreductase -
PIC05_RS04235 (871731) 871731..873164 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
PIC05_RS04240 (873209) 873209..873520 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PIC05_RS04245 (873684) 873684..874343 + 660 WP_000250274.1 hemolysin III family protein -
PIC05_RS04250 (874539) 874539..875519 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PIC05_RS04255 (875762) 875762..876028 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC05_RS04260 (876009) 876009..876416 + 408 WP_000244783.1 protein YgfX Toxin
PIC05_RS04265 (876456) 876456..876977 - 522 WP_001055874.1 flavodoxin FldB -
PIC05_RS04270 (877089) 877089..877985 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIC05_RS04275 (878010) 878010..878720 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC05_RS04280 (878726) 878726..880459 + 1734 WP_241226228.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T267987 WP_000244783.1 NZ_CP116106:876009-876416 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267987 WP_000354046.1 NZ_CP116106:875762-876028 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References