Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1435814..1436445 Replicon chromosome
Accession NC_017452
Organism Haemophilus influenzae R2846

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag R2846_RS06920 Protein ID WP_005651560.1
Coordinates 1436047..1436445 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag R2846_RS06915 Protein ID WP_005648011.1
Coordinates 1435814..1436047 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2846_RS06890 1431293..1432495 - 1203 WP_014550998.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
R2846_RS06895 1432658..1433323 + 666 WP_013527272.1 DNA repair protein RadC -
R2846_RS06900 1433537..1433773 + 237 WP_005542826.1 50S ribosomal protein L28 -
R2846_RS06905 1433785..1433955 + 171 WP_005613503.1 50S ribosomal protein L33 -
R2846_RS06910 1434303..1435667 + 1365 WP_014550999.1 diaminobutyrate--2-oxoglutarate transaminase -
R2846_RS06915 1435814..1436047 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
R2846_RS06920 1436047..1436445 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
R2846_RS06925 1436465..1438000 + 1536 WP_014551000.1 L-2,4-diaminobutyrate decarboxylase -
R2846_RS06930 1438231..1439046 + 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
R2846_RS06935 1439120..1440142 - 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
R2846_RS06940 1440143..1441261 - 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T26798 WP_005651560.1 NC_017452:1436047-1436445 [Haemophilus influenzae R2846]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T26798 NC_017452:1436047-1436445 [Haemophilus influenzae R2846]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT26798 WP_005648011.1 NC_017452:1435814-1436047 [Haemophilus influenzae R2846]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT26798 NC_017452:1435814-1436047 [Haemophilus influenzae R2846]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References