Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3763583..3764237 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PIB67_RS18320 Protein ID WP_000244781.1
Coordinates 3763583..3763990 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIB67_RS18325 Protein ID WP_000354046.1
Coordinates 3763971..3764237 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS18300 (3759540) 3759540..3761273 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
PIB67_RS18305 (3761279) 3761279..3761989 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIB67_RS18310 (3762014) 3762014..3762910 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIB67_RS18315 (3763022) 3763022..3763543 + 522 WP_001055874.1 flavodoxin FldB -
PIB67_RS18320 (3763583) 3763583..3763990 - 408 WP_000244781.1 protein YgfX Toxin
PIB67_RS18325 (3763971) 3763971..3764237 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIB67_RS18330 (3764480) 3764480..3765460 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
PIB67_RS18335 (3765537) 3765537..3766196 - 660 WP_000250274.1 hemolysin III family protein -
PIB67_RS18340 (3766360) 3766360..3766671 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
PIB67_RS18345 (3766716) 3766716..3768149 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T267976 WP_000244781.1 NZ_CP116103:c3763990-3763583 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267976 WP_000354046.1 NZ_CP116103:c3764237-3763971 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References