267965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 728480..729030 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag PIB67_RS03525 Protein ID WP_001160966.1
Coordinates 728716..729030 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag PIB67_RS03520 Protein ID WP_000125568.1
Coordinates 728480..728713 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS03495 (723553) 723553..723840 + 288 WP_000203741.1 ferredoxin-like protein FixX -
PIB67_RS03500 (723899) 723899..725230 + 1332 WP_001183207.1 MFS transporter -
PIB67_RS03505 (725338) 725338..725868 + 531 WP_000600732.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
PIB67_RS03510 (725861) 725861..727723 + 1863 WP_000377109.1 glutathione-regulated potassium-efflux system protein KefC -
PIB67_RS03515 (727915) 727915..728394 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
PIB67_RS03520 (728480) 728480..728713 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PIB67_RS03525 (728716) 728716..729030 + 315 WP_001160966.1 CcdB family protein Toxin
PIB67_RS03530 (729027) 729027..729875 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
PIB67_RS03535 (729882) 729882..730259 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
PIB67_RS03540 (730262) 730262..731083 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
PIB67_RS03545 (731080) 731080..732069 - 990 WP_000241225.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
PIB67_RS03550 (732069) 732069..733355 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T267965 WP_001160966.1 NZ_CP116103:728716-729030 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT267965 WP_000125568.1 NZ_CP116103:728480-728713 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References