Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 139531..140174 Replicon plasmid pDETEC23
Accession NZ_CP116101
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag PIC52_RS23460 Protein ID WP_001034044.1
Coordinates 139758..140174 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag PIC52_RS23455 Protein ID WP_001261286.1
Coordinates 139531..139761 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS23440 (134668) 134668..134898 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
PIC52_RS23445 (134895) 134895..135311 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
PIC52_RS23450 (135356) 135356..139150 - 3795 WP_001144731.1 hypothetical protein -
PIC52_RS23455 (139531) 139531..139761 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIC52_RS23460 (139758) 139758..140174 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC52_RS23465 (140249) 140249..141814 + 1566 WP_001128474.1 AAA family ATPase -
PIC52_RS23470 (141799) 141799..142821 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / qnrS1 / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..178682 178682
- flank IS/Tn - - 143075..143578 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T267955 WP_001034044.1 NZ_CP116101:139758-140174 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT267955 WP_001261286.1 NZ_CP116101:139531-139761 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References