Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 128637..128974 Replicon chromosome
Accession NC_017452
Organism Haemophilus influenzae R2846

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag R2846_RS00660 Protein ID WP_005686917.1
Coordinates 128837..128974 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag R2846_RS00655 Protein ID WP_005649350.1
Coordinates 128637..128828 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2846_RS00630 124216..124848 + 633 WP_005686927.1 dTMP kinase -
R2846_RS00635 124845..125828 + 984 WP_014550403.1 DNA polymerase III subunit delta' -
R2846_RS00640 125883..126665 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
R2846_RS00645 126692..127216 + 525 WP_005686921.1 DUF1523 family protein -
R2846_RS00650 127267..128565 + 1299 WP_014550404.1 hemolysin family protein -
R2846_RS00655 128637..128828 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
R2846_RS00660 128837..128974 + 138 WP_005686917.1 hypothetical protein Toxin
R2846_RS00665 129067..129597 + 531 WP_005662583.1 hypothetical protein -
R2846_RS00670 129669..131168 + 1500 WP_014550406.1 fused PTS fructose transporter subunit IIA/HPr protein -
R2846_RS00675 131170..132111 + 942 WP_014550407.1 1-phosphofructokinase -
R2846_RS00680 132113..133783 + 1671 WP_014550408.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T26795 WP_005686917.1 NC_017452:128837-128974 [Haemophilus influenzae R2846]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T26795 NC_017452:128837-128974 [Haemophilus influenzae R2846]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT26795 WP_005649350.1 NC_017452:128637-128828 [Haemophilus influenzae R2846]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT26795 NC_017452:128637-128828 [Haemophilus influenzae R2846]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References