Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3905563..3906217 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag PIC52_RS18945 Protein ID WP_000244765.1
Coordinates 3905810..3906217 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC52_RS18940 Protein ID WP_000354046.1
Coordinates 3905563..3905829 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS18920 (3901651) 3901651..3903084 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
PIC52_RS18925 (3903129) 3903129..3903440 + 312 WP_001525592.1 N(4)-acetylcytidine aminohydrolase -
PIC52_RS18930 (3903604) 3903604..3904263 + 660 WP_000250275.1 hemolysin III family protein -
PIC52_RS18935 (3904340) 3904340..3905320 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
PIC52_RS18940 (3905563) 3905563..3905829 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC52_RS18945 (3905810) 3905810..3906217 + 408 WP_000244765.1 protein YgfX Toxin
PIC52_RS18950 (3906257) 3906257..3906778 - 522 WP_001055874.1 flavodoxin FldB -
PIC52_RS18955 (3906890) 3906890..3907786 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIC52_RS18960 (3907811) 3907811..3908521 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC52_RS18965 (3908527) 3908527..3910260 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T267948 WP_000244765.1 NZ_CP116100:3905810-3906217 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267948 WP_000354046.1 NZ_CP116100:3905563-3905829 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References