Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3315140..3315735 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name doc Uniprot ID A0A826P6U8
Locus tag PIC52_RS15970 Protein ID WP_000155160.1
Coordinates 3315358..3315735 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D6JG32
Locus tag PIC52_RS15965 Protein ID WP_000557315.1
Coordinates 3315140..3315361 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS15940 (3310216) 3310216..3311325 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PIC52_RS15945 (3311373) 3311373..3312299 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PIC52_RS15950 (3312296) 3312296..3313573 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
PIC52_RS15955 (3313570) 3313570..3314337 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PIC52_RS15960 (3314339) 3314339..3315052 + 714 WP_000416895.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
PIC52_RS15965 (3315140) 3315140..3315361 + 222 WP_000557315.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PIC52_RS15970 (3315358) 3315358..3315735 + 378 WP_000155160.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PIC52_RS15975 (3315944) 3315944..3317260 + 1317 WP_001606337.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
PIC52_RS15980 (3317358) 3317358..3318245 + 888 WP_001606336.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
PIC52_RS15985 (3318242) 3318242..3319087 + 846 WP_000572183.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
PIC52_RS15990 (3319089) 3319089..3320159 + 1071 WP_000907823.1 sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3312296..3320899 8603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13945.20 Da        Isoelectric Point: 6.4830

>T267945 WP_000155160.1 NZ_CP116100:3315358-3315735 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGLILAANPEFVELTVDVAAGKVSLEDIVTRLRQHGT

Download         Length: 378 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.24 Da        Isoelectric Point: 6.2168

>AT267945 WP_000557315.1 NZ_CP116100:3315140-3315361 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A826P6U8


Antitoxin

Source ID Structure
AlphaFold DB D6JG32

References