Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3308613..3309413 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag PIC52_RS15930 Protein ID WP_000342452.1
Coordinates 3308886..3309413 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag PIC52_RS15925 Protein ID WP_001277107.1
Coordinates 3308613..3308879 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS15905 (3304272) 3304272..3304940 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
PIC52_RS15910 (3304933) 3304933..3305991 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
PIC52_RS15915 (3306236) 3306236..3307090 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PIC52_RS15920 (3307361) 3307361..3308464 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PIC52_RS15925 (3308613) 3308613..3308879 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PIC52_RS15930 (3308886) 3308886..3309413 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PIC52_RS15935 (3309410) 3309410..3309793 - 384 WP_000778810.1 aspartate 1-decarboxylase autocleavage activator PanM -
PIC52_RS15940 (3310216) 3310216..3311325 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PIC52_RS15945 (3311373) 3311373..3312299 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PIC52_RS15950 (3312296) 3312296..3313573 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
PIC52_RS15955 (3313570) 3313570..3314337 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T267944 WP_000342452.1 NZ_CP116100:3308886-3309413 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT267944 WP_001277107.1 NZ_CP116100:3308613-3308879 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References