Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2488374..2488871 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC52_RS12175 Protein ID WP_001173343.1
Coordinates 2488374..2488547 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag PIC52_RS12180 Protein ID WP_001312331.1
Coordinates 2488575..2488871 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS12165 (2485044) 2485044..2486501 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
PIC52_RS12170 (2486738) 2486738..2488255 + 1518 WP_000003806.1 lysine--tRNA ligase -
PIC52_RS12175 (2488374) 2488374..2488547 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC52_RS12180 (2488575) 2488575..2488871 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC52_RS12185 (2489099) 2489099..2489371 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIC52_RS12190 (2489585) 2489585..2493514 - 3930 WP_001606659.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-55 papB / papI 2411601..2504558 92957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T267940 WP_001173343.1 NZ_CP116100:c2488547-2488374 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT267940 WP_001312331.1 NZ_CP116100:c2488871-2488575 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References