Detailed information of TA system TA026794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1855982..1856453
• Replicon: chromosome
• Accession: NC_017451
• Organism: Haemophilus influenzae R2866

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: R2866_RS09110
• Protein ID: WP_005654546.1
• Coordinates: 1855982..1856164 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: R2866_RS09115
• Protein ID: WP_005650837.1
• Coordinates: 1856157..1856453 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2866_RS09105	1852671..1855712	+	3042	WP_020910211.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
R2866_RS09110	1855982..1856164	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
R2866_RS09115	1856157..1856453	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
R2866_RS09120	1856637..1858553	+	1917	WP_020910212.1	ABC transporter ATP-binding protein	-
R2866_RS09125	1858563..1859099	+	537	WP_020910213.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
R2866_RS09130	1859115..1859666	+	552	WP_020910214.1	Sua5/YciO/YrdC/YwlC family protein	-
R2866_RS09135	1859670..1860476	+	807	WP_020910215.1	shikimate dehydrogenase	-
R2866_RS09140	1860488..1861240	+	753	WP_020910216.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T26794 WP_005654546.1 NC_017451:1855982-1856164 [Haemophilus influenzae R2866]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T26794 NC_017451:1855982-1856164 [Haemophilus influenzae R2866]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT26794 WP_005650837.1 NC_017451:1856157-1856453 [Haemophilus influenzae R2866]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT26794 NC_017451:1856157-1856453 [Haemophilus influenzae R2866]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGAAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9