Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1677959..1678577 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC52_RS08335 Protein ID WP_001291435.1
Coordinates 1678359..1678577 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC52_RS08330 Protein ID WP_000344800.1
Coordinates 1677959..1678333 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS08320 (1673049) 1673049..1674242 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC52_RS08325 (1674265) 1674265..1677414 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
PIC52_RS08330 (1677959) 1677959..1678333 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC52_RS08335 (1678359) 1678359..1678577 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC52_RS08340 (1678751) 1678751..1679302 + 552 WP_001606934.1 maltose O-acetyltransferase -
PIC52_RS08345 (1679418) 1679418..1679888 + 471 WP_000136192.1 YlaC family protein -
PIC52_RS08350 (1680052) 1680052..1681602 + 1551 WP_001606933.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC52_RS08355 (1681644) 1681644..1681997 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC52_RS08365 (1682376) 1682376..1682687 + 312 WP_000409908.1 MGMT family protein -
PIC52_RS08370 (1682718) 1682718..1683290 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267936 WP_001291435.1 NZ_CP116100:1678359-1678577 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267936 WP_000344800.1 NZ_CP116100:1677959-1678333 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References