Detailed information of TA system TA026792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1471992..1472623
• Replicon: chromosome
• Accession: NC_017451
• Organism: Haemophilus influenzae R2866

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: R2866_RS07195
• Protein ID: WP_005648013.1
• Coordinates: 1472225..1472623 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q4QLV9
• Locus tag: R2866_RS07190
• Protein ID: WP_005648011.1
• Coordinates: 1471992..1472225 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2866_RS07165	1467470..1468672	-	1203	WP_005666020.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
R2866_RS07170	1468836..1469501	+	666	WP_020910156.1	DNA repair protein RadC	-
R2866_RS07175	1469715..1469951	+	237	WP_005542826.1	50S ribosomal protein L28	-
R2866_RS07180	1469963..1470133	+	171	WP_005613503.1	50S ribosomal protein L33	-
R2866_RS07185	1470481..1471845	+	1365	WP_005648009.1	diaminobutyrate--2-oxoglutarate transaminase	-
R2866_RS07190	1471992..1472225	+	234	WP_005648011.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
R2866_RS07195	1472225..1472623	+	399	WP_005648013.1	tRNA(fMet)-specific endonuclease VapC	Toxin
R2866_RS07200	1472643..1474178	+	1536	WP_005648022.1	L-2,4-diaminobutyrate decarboxylase	-
R2866_RS07205	1474410..1475225	+	816	WP_005666022.1	DNA-formamidopyrimidine glycosylase	-
R2866_RS07210	1475299..1476318	-	1020	WP_005666023.1	outer membrane-stress sensor serine endopeptidase DegS	-
R2866_RS07215	1476319..1477437	-	1119	WP_005666024.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15073.38 Da
• Isoelectric Point: 8.0514

>T26792 WP_005648013.1 NC_017451:1472225-1472623 [Haemophilus influenzae R2866]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAGIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Nucleotide

• Length: 399 bp

>T26792 NC_017451:1472225-1472623 [Haemophilus influenzae R2866]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGGTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8880.98 Da
• Isoelectric Point: 4.4013

>AT26792 WP_005648011.1 NC_017451:1471992-1472225 [Haemophilus influenzae R2866]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT26792 NC_017451:1471992-1472225 [Haemophilus influenzae R2866]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Structures

Antitoxin

• AlphaFold DB: A0A806DGS0