Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 49609..50234 Replicon plasmid pDETEC68
Accession NZ_CP116095
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PIC78_RS24250 Protein ID WP_000911313.1
Coordinates 49836..50234 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PIC78_RS24245 Protein ID WP_000450520.1
Coordinates 49609..49836 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS24245 (49609) 49609..49836 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC78_RS24250 (49836) 49836..50234 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC78_RS24255 (50243) 50243..52396 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
PIC78_RS24260 (52649) 52649..53380 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PIC78_RS24265 (53412) 53412..53909 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / sitABCD iutA / iucD / iucC / iucB / iucA 1..102896 102896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T267919 WP_000911313.1 NZ_CP116095:49836-50234 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT267919 WP_000450520.1 NZ_CP116095:49609-49836 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References