Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1174602..1175191 Replicon chromosome
Accession NC_017451
Organism Haemophilus influenzae R2866

Toxin (Protein)


Gene name hicA Uniprot ID O87469
Locus tag R2866_RS05765 Protein ID WP_005668369.1
Coordinates 1174943..1175191 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag R2866_RS05760 Protein ID WP_005668366.1
Coordinates 1174602..1174946 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2866_RS05745 1170240..1172753 - 2514 WP_005668359.1 fimbrial biogenesis outer membrane usher protein -
R2866_RS05750 1172848..1173546 - 699 WP_032826232.1 fimbria/pilus periplasmic chaperone -
R2866_RS05755 1173867..1174505 + 639 WP_005668364.1 type 1 fimbrial protein -
R2866_RS05760 1174602..1174946 - 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
R2866_RS05765 1174943..1175191 - 249 WP_005668369.1 type II toxin-antitoxin system HicA family toxin Toxin
R2866_RS05770 1175362..1175856 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
R2866_RS05775 1175926..1177014 + 1089 WP_005668373.1 5-(carboxyamino)imidazole ribonucleotide synthase -
R2866_RS05780 1177154..1178344 + 1191 WP_020910100.1 aspartate/tyrosine/aromatic aminotransferase -
R2866_RS09825 1178427..1178558 - 132 Protein_1118 hydrogenase expression/formation protein HypE -
R2866_RS05785 1178565..1179182 - 618 WP_005667285.1 energy-coupling factor ABC transporter ATP-binding protein -
R2866_RS05790 1179184..1179816 - 633 WP_005667287.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9455.95 Da        Isoelectric Point: 10.4673

>T26791 WP_005668369.1 NC_017451:c1175191-1174943 [Haemophilus influenzae R2866]
MGRTEKLLDKLAQSKSTFNWNELVSLLTQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T26791 NC_017451:c1175191-1174943 [Haemophilus influenzae R2866]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AACTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT26791 WP_005668366.1 NC_017451:c1174946-1174602 [Haemophilus influenzae R2866]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp

>AT26791 NC_017451:c1174946-1174602 [Haemophilus influenzae R2866]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCGATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DKW8

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References