Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1087642..1088260 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC78_RS05235 Protein ID WP_001291435.1
Coordinates 1087642..1087860 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC78_RS05240 Protein ID WP_000344800.1
Coordinates 1087886..1088260 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS05200 (1082931) 1082931..1083503 + 573 WP_000779831.1 YbaY family lipoprotein -
PIC78_RS05205 (1083534) 1083534..1083845 - 312 WP_000409911.1 MGMT family protein -
PIC78_RS05215 (1084224) 1084224..1084577 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC78_RS05220 (1084619) 1084619..1086169 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC78_RS05225 (1086333) 1086333..1086803 - 471 WP_000136192.1 YlaC family protein -
PIC78_RS05230 (1086919) 1086919..1087470 - 552 WP_000102564.1 maltose O-acetyltransferase -
PIC78_RS05235 (1087642) 1087642..1087860 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC78_RS05240 (1087886) 1087886..1088260 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC78_RS05245 (1088806) 1088806..1091955 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC78_RS05250 (1091978) 1091978..1093171 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267900 WP_001291435.1 NZ_CP116094:c1087860-1087642 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267900 WP_000344800.1 NZ_CP116094:c1088260-1087886 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References