Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 387627..388222 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PIC78_RS01850 Protein ID WP_000239579.1
Coordinates 387872..388222 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PIC78_RS01845 Protein ID WP_001223208.1
Coordinates 387627..387878 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS01835 (383292) 383292..387071 + 3780 WP_000060978.1 autotransporter assembly complex protein TamB -
PIC78_RS01840 (387074) 387074..387415 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PIC78_RS01845 (387627) 387627..387878 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PIC78_RS01850 (387872) 387872..388222 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PIC78_RS01855 (388302) 388302..388832 - 531 WP_000055072.1 inorganic diphosphatase -
PIC78_RS01860 (389142) 389142..390098 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PIC78_RS01865 (390238) 390238..391740 + 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
PIC78_RS01870 (391754) 391754..392776 + 1023 WP_001295197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T267896 WP_000239579.1 NZ_CP116094:387872-388222 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT267896 WP_001223208.1 NZ_CP116094:387627-387878 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References