Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 531899..532505 Replicon chromosome
Accession NC_017451
Organism Haemophilus influenzae R2866

Toxin (Protein)


Gene name hicA Uniprot ID A0A2V0SD64
Locus tag R2866_RS09585 Protein ID WP_005667742.1
Coordinates 531899..532075 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A806ED58
Locus tag R2866_RS02655 Protein ID WP_005642973.1
Coordinates 532104..532505 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2866_RS02615 526943..527446 + 504 WP_015967400.1 hypothetical protein -
R2866_RS02620 527465..527833 + 369 WP_005667757.1 hypothetical protein -
R2866_RS02625 527833..528018 + 186 WP_005667755.1 hypothetical protein -
R2866_RS02630 528030..528311 + 282 WP_015967401.1 hypothetical protein -
R2866_RS02635 528362..528622 + 261 WP_005667751.1 hypothetical protein -
R2866_RS02640 528625..530952 + 2328 WP_005667749.1 replication endonuclease -
R2866_RS02645 530964..531275 + 312 WP_005667746.1 hypothetical protein -
R2866_RS02650 531285..531803 + 519 WP_005667744.1 phage N-6-adenine-methyltransferase -
R2866_RS09585 531899..532075 + 177 WP_005667742.1 type II toxin-antitoxin system HicA family toxin Toxin
R2866_RS02655 532104..532505 + 402 WP_005642973.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
R2866_RS09590 532532..532792 - 261 WP_071819916.1 ogr/Delta-like zinc finger family protein -
R2866_RS02660 532871..533908 - 1038 WP_005667739.1 phage portal protein -
R2866_RS02665 533898..535721 - 1824 WP_015967402.1 terminase ATPase subunit family protein -
R2866_RS02670 535925..536818 + 894 WP_005667735.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6632.65 Da        Isoelectric Point: 10.3659

>T26789 WP_005667742.1 NC_017451:531899-532075 [Haemophilus influenzae R2866]
VDSKTAIKMIEEDGWYLDRVKGSHHQYKHPTKKGTVTIPHPRKDLGHLEKSIKKQAGL

Download         Length: 177 bp

>T26789 NC_017451:531899-532075 [Haemophilus influenzae R2866]
GTGGATAGCAAAACAGCAATAAAAATGATAGAAGAGGACGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATA
CAAACATCCTACAAAAAAGGGAACGGTCACGATTCCCCACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAA
AACAAGCGGGGCTGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14922.06 Da        Isoelectric Point: 4.3937

>AT26789 WP_005642973.1 NC_017451:532104-532505 [Haemophilus influenzae R2866]
MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVD
VDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA

Download         Length: 402 bp

>AT26789 NC_017451:532104-532505 [Haemophilus influenzae R2866]
ATGTTATACCCGATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCGATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCAGAAAAAATTAATATTACGGTTCCAGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACCCATCCAGAATATAAGAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V0SD64

Antitoxin

Source ID Structure
AlphaFold DB A0A806ED58

References