Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 142680..143305 Replicon plasmid pDETEC72
Accession NZ_CP116089
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PIC22_RS24115 Protein ID WP_000911313.1
Coordinates 142907..143305 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PIC22_RS24110 Protein ID WP_000450520.1
Coordinates 142680..142907 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS24110 (142680) 142680..142907 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC22_RS24115 (142907) 142907..143305 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC22_RS24120 (143314) 143314..145467 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
PIC22_RS24125 (145720) 145720..146451 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PIC22_RS24130 (146483) 146483..146980 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(A) / qnrS1 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..187674 187674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T267886 WP_000911313.1 NZ_CP116089:142907-143305 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT267886 WP_000450520.1 NZ_CP116089:142680-142907 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References