Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4385361..4385986 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PIC22_RS21290 Protein ID WP_000911329.1
Coordinates 4385588..4385986 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PIC22_RS21285 Protein ID WP_000450524.1
Coordinates 4385361..4385588 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS21260 (4381163) 4381163..4381633 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PIC22_RS21265 (4381633) 4381633..4382205 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
PIC22_RS21270 (4382351) 4382351..4383229 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PIC22_RS21275 (4383246) 4383246..4384280 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PIC22_RS21280 (4384493) 4384493..4385206 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PIC22_RS21285 (4385361) 4385361..4385588 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC22_RS21290 (4385588) 4385588..4385986 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC22_RS21295 (4386133) 4386133..4386996 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PIC22_RS21300 (4387011) 4387011..4389026 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
PIC22_RS21305 (4389100) 4389100..4389798 + 699 WP_000679823.1 esterase -
PIC22_RS21310 (4389908) 4389908..4390108 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T267881 WP_000911329.1 NZ_CP116088:4385588-4385986 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT267881 WP_000450524.1 NZ_CP116088:4385361-4385588 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References