Detailed information of TA system TA026788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 247657..248294
• Replicon: chromosome
• Accession: NC_017451
• Organism: Haemophilus influenzae R2866

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: R2866_RS01260
• Protein ID: WP_005649049.1
• Coordinates: 247657..248061 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: R2866_RS01265
• Protein ID: WP_005649046.1
• Coordinates: 248058..248294 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2866_RS01230	243213..243779	+	567	WP_005544066.1	elongation factor P	-
R2866_RS01240	244127..244720	-	594	WP_005666656.1	primosomal replication protein	-
R2866_RS01245	244753..246105	-	1353	WP_005649062.1	Na+/H+ antiporter family protein	-
R2866_RS01250	246420..247109	-	690	WP_005649060.1	ribonuclease T	-
R2866_RS01255	247183..247590	-	408	WP_005654069.1	lactoylglutathione lyase	-
R2866_RS01260	247657..248061	-	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
R2866_RS01265	248058..248294	-	237	WP_005649046.1	antitoxin	Antitoxin
R2866_RS01270	248387..249112	-	726	WP_005649042.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
R2866_RS01275	249165..249683	-	519	WP_005649040.1	isoprenylcysteine carboxyl methyltransferase family protein	-
R2866_RS01280	249902..251668	+	1767	WP_005649039.1	aspartate--tRNA ligase	-
R2866_RS01285	251690..252163	+	474	WP_005666660.1	dihydroneopterin triphosphate diphosphatase	-
R2866_RS01290	252175..252915	+	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T26788 WP_005649049.1 NC_017451:c248061-247657 [Haemophilus influenzae R2866]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T26788 NC_017451:c248061-247657 [Haemophilus influenzae R2866]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT26788 WP_005649046.1 NC_017451:c248294-248058 [Haemophilus influenzae R2866]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT26788 NC_017451:c248294-248058 [Haemophilus influenzae R2866]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3