Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3629147..3629644 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC22_RS17765 Protein ID WP_001173343.1
Coordinates 3629471..3629644 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PIC22_RS17760 Protein ID WP_000398619.1
Coordinates 3629147..3629443 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS17740 (3625878) 3625878..3626597 - 720 WP_000611288.1 two-component system response regulator DcuR -
PIC22_RS17745 (3626594) 3626594..3628225 - 1632 WP_001216461.1 sensor histidine kinase -
PIC22_RS17750 (3628406) 3628406..3628636 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PIC22_RS17755 (3628648) 3628648..3628920 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIC22_RS17760 (3629147) 3629147..3629443 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC22_RS17765 (3629471) 3629471..3629644 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC22_RS17770 (3629763) 3629763..3631280 - 1518 WP_001295074.1 lysine--tRNA ligase -
PIC22_RS17775 (3631517) 3631517..3632974 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T267879 WP_001173343.1 NZ_CP116088:3629471-3629644 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT267879 WP_000398619.1 NZ_CP116088:3629147-3629443 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References