Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2878659..2879245 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PIC22_RS14330 Protein ID WP_042014162.1
Coordinates 2879015..2879245 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PIC22_RS14325 Protein ID WP_000593555.1
Coordinates 2878659..2879018 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS14300 (2874791) 2874791..2875735 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
PIC22_RS14305 (2875732) 2875732..2876565 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PIC22_RS14310 (2876565) 2876565..2877329 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PIC22_RS14315 (2877326) 2877326..2878132 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PIC22_RS14320 (2878138) 2878138..2878539 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PIC22_RS14325 (2878659) 2878659..2879018 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PIC22_RS14330 (2879015) 2879015..2879245 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PIC22_RS14335 (2879349) 2879349..2880473 - 1125 WP_001216257.1 ABC transporter permease -
PIC22_RS14340 (2880473) 2880473..2883208 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T267877 WP_042014162.1 NZ_CP116088:c2879245-2879015 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT267877 WP_000593555.1 NZ_CP116088:c2879018-2878659 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References