267873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1850147..1850984 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PIC22_RS09140 Protein ID WP_000227784.1
Coordinates 1850442..1850984 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PIC22_RS09135 Protein ID WP_001297137.1
Coordinates 1850147..1850458 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS09110 (1845167) 1845167..1846114 + 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -
PIC22_RS09115 (1846136) 1846136..1848127 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PIC22_RS09120 (1848117) 1848117..1848731 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PIC22_RS09125 (1848731) 1848731..1849060 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PIC22_RS09130 (1849072) 1849072..1849962 + 891 WP_000971336.1 heme o synthase -
PIC22_RS09135 (1850147) 1850147..1850458 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PIC22_RS09140 (1850442) 1850442..1850984 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PIC22_RS09145 (1851040) 1851040..1851975 - 936 WP_001297127.1 tetratricopeptide repeat protein -
PIC22_RS09150 (1852383) 1852383..1853747 + 1365 WP_001000978.1 MFS transporter -
PIC22_RS09155 (1853875) 1853875..1854366 - 492 WP_001138904.1 nucleotide binding protein YajQ -
PIC22_RS09160 (1854534) 1854534..1855445 + 912 WP_000705849.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T267873 WP_000227784.1 NZ_CP116088:1850442-1850984 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT267873 WP_001297137.1 NZ_CP116088:1850147-1850458 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References