Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1816070..1816688 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC22_RS08970 Protein ID WP_001291435.1
Coordinates 1816470..1816688 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC22_RS08965 Protein ID WP_000344800.1
Coordinates 1816070..1816444 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS08955 (1811159) 1811159..1812352 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC22_RS08960 (1812375) 1812375..1815524 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC22_RS08965 (1816070) 1816070..1816444 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC22_RS08970 (1816470) 1816470..1816688 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC22_RS08975 (1816859) 1816859..1817410 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIC22_RS08980 (1817526) 1817526..1817996 + 471 WP_000136192.1 YlaC family protein -
PIC22_RS08985 (1818160) 1818160..1819710 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC22_RS08990 (1819752) 1819752..1820105 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC22_RS09000 (1820484) 1820484..1820795 + 312 WP_000409911.1 MGMT family protein -
PIC22_RS09005 (1820826) 1820826..1821398 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267872 WP_001291435.1 NZ_CP116088:1816470-1816688 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267872 WP_000344800.1 NZ_CP116088:1816070-1816444 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References