Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 750446..751084 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PIC22_RS03780 Protein ID WP_000813794.1
Coordinates 750908..751084 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC22_RS03775 Protein ID WP_001270285.1
Coordinates 750446..750862 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS03755 (745598) 745598..746539 - 942 WP_001251315.1 ABC transporter permease -
PIC22_RS03760 (746540) 746540..747553 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
PIC22_RS03765 (747571) 747571..748716 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PIC22_RS03770 (748961) 748961..750367 - 1407 WP_000760594.1 PLP-dependent aminotransferase family protein -
PIC22_RS03775 (750446) 750446..750862 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC22_RS03780 (750908) 750908..751084 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC22_RS03785 (751306) 751306..751536 + 231 WP_000494244.1 YncJ family protein -
PIC22_RS03790 (751628) 751628..753589 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC22_RS03795 (753662) 753662..754198 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PIC22_RS03800 (754290) 754290..755465 + 1176 WP_001236268.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 755505..756653 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T267871 WP_000813794.1 NZ_CP116088:c751084-750908 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT267871 WP_001270285.1 NZ_CP116088:c750862-750446 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References