26787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 125803..126140 Replicon chromosome
Accession NC_017451
Organism Haemophilus influenzae R2866

Toxin (Protein)


Gene name VapD Uniprot ID A0A806DEN6
Locus tag R2866_RS00625 Protein ID WP_005652099.1
Coordinates 126003..126140 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag R2866_RS00620 Protein ID WP_005649350.1
Coordinates 125803..125994 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2866_RS00600 122011..122994 + 984 WP_005666498.1 DNA polymerase III subunit delta' -
R2866_RS00605 123049..123831 + 783 WP_005649353.1 YchF/TatD family DNA exonuclease -
R2866_RS00610 123858..124382 + 525 WP_005649352.1 DUF1523 family protein -
R2866_RS00615 124433..125731 + 1299 WP_005691371.1 hemolysin family protein -
R2866_RS00620 125803..125994 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
R2866_RS00625 126003..126140 + 138 WP_005652099.1 hypothetical protein Toxin
R2866_RS00630 126233..126763 + 531 WP_005649345.1 hypothetical protein -
R2866_RS00635 126835..128334 + 1500 WP_005649342.1 fused PTS fructose transporter subunit IIA/HPr protein -
R2866_RS00640 128336..129277 + 942 WP_005649339.1 1-phosphofructokinase -
R2866_RS00645 129279..130949 + 1671 WP_005649337.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5256.88 Da        Isoelectric Point: 4.6701

>T26787 WP_005652099.1 NC_017451:126003-126140 [Haemophilus influenzae R2866]
MYAIAFDLVVKGTQDYHPKGVQQAYTDIGAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T26787 NC_017451:126003-126140 [Haemophilus influenzae R2866]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGGCACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGTGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT26787 WP_005649350.1 NC_017451:125803-125994 [Haemophilus influenzae R2866]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT26787 NC_017451:125803-125994 [Haemophilus influenzae R2866]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTATTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DEN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References