Detailed information of TA system TA026786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2628725..2630446
• Replicon: chromosome
• Accession: NC_017448
• Organism: Fibrobacter succinogenes subsp. succinogenes S85

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: C9RS34
• Locus tag: FSU_RS10810
• Protein ID: WP_014546446.1
• Coordinates: 2628725..2630020 (-)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: FSU_RS10815
• Protein ID: WP_014546447.1
• Coordinates: 2630030..2630446 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSU_RS10800	2626079..2628145	+	2067	WP_014546444.1	family 43 glycosylhydrolase	-
FSU_RS10805	2628262..2628735	+	474	WP_015732108.1	hypothetical protein	-
FSU_RS10810	2628725..2630020	-	1296	WP_014546446.1	type II toxin-antitoxin system HipA family toxin	Toxin
FSU_RS10815	2630030..2630446	-	417	WP_014546447.1	helix-turn-helix domain-containing protein	Antitoxin
FSU_RS10820	2630584..2631663	+	1080	WP_014546448.1	DUF285 domain-containing protein	-
FSU_RS10825	2631727..2632635	+	909	WP_014546449.1	hypothetical protein	-
FSU_RS10830	2632647..2633000	-	354	WP_015732109.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-73)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 48321.29 Da
• Isoelectric Point: 8.7287

>T26786 WP_014546446.1 NC_017448:c2630020-2628725 [Fibrobacter succinogenes subsp. succinogenes S85]
MIAVEVKLWGTTIGALSMMEGESVARFEYAPNFIGAGIEPSPIAMPVSRQIYSFPMLSKTFHGLPGLFADSLPDKFGNSI
IDTWLLRQGRSPESFTALERLCYTGNRGMGALEFFPLQGPDSTTDDSLNVENLRILAAEVLNQRKRFSTKALSKKGNKSF
EEILRVGTSAGGARAKILVAYDEESGEMHSGQVATDPRFGYWLLKLDDVTNNRDKESADLFGYGAIEYSYSQMAKLAGIE
MTECRLYECAGHRHFMTRRFDRLAGGKKLHYQSLCGIAHYDFNMPGAYSYEQALNVIKRLELGYDALEEMYRRAAFNICA
RNQDDHAKNIGFLMDKRGVWTLAPAFDMTYAYNPQGTWTGTHQMTFNGKRSGFKLDDFKAVAKFAGLKQGRYKKILAEVE
DAVMQWKKLAKQNGVPIRIARAIAGVHEFIL

Nucleotide

• Length: 1296 bp

>T26786 NC_017448:c2630020-2628725 [Fibrobacter succinogenes subsp. succinogenes S85]
ATGATTGCGGTGGAAGTAAAACTTTGGGGAACGACAATCGGGGCGCTTTCAATGATGGAAGGCGAAAGCGTTGCGCGTTT
TGAATACGCGCCGAACTTTATCGGGGCGGGCATTGAGCCCTCACCCATCGCCATGCCGGTCTCTCGGCAGATTTATTCGT
TCCCGATGTTATCAAAGACATTTCATGGACTGCCTGGGCTTTTTGCAGATAGCCTCCCGGACAAGTTCGGCAATAGCATT
ATTGACACATGGCTTTTACGGCAAGGGCGTTCACCAGAAAGTTTCACAGCACTCGAACGCTTGTGTTATACGGGCAACCG
GGGCATGGGCGCACTGGAGTTTTTTCCATTACAGGGACCAGATTCTACAACGGACGATTCTTTAAACGTTGAAAACTTGA
GAATTTTAGCAGCGGAAGTCTTGAATCAGCGCAAACGATTTTCAACAAAAGCTCTCAGCAAAAAAGGAAACAAATCGTTT
GAAGAAATACTCAGGGTCGGCACGTCTGCGGGCGGCGCTCGTGCAAAAATCCTTGTGGCCTACGATGAGGAAAGTGGTGA
AATGCATTCAGGGCAAGTGGCGACCGATCCGAGATTTGGCTATTGGCTTTTGAAACTTGACGACGTTACAAACAACCGCG
ACAAAGAAAGTGCAGACTTGTTCGGCTACGGAGCTATTGAATATTCTTATTCGCAAATGGCAAAACTTGCGGGTATTGAA
ATGACAGAATGCCGACTCTACGAATGTGCGGGCCATAGGCATTTTATGACGAGACGTTTTGACCGTCTAGCGGGCGGAAA
GAAATTGCATTACCAGTCGCTTTGCGGCATCGCCCATTACGATTTCAACATGCCGGGAGCATACAGTTACGAACAGGCGC
TAAATGTAATCAAGCGACTTGAACTCGGTTATGACGCGCTTGAAGAAATGTATCGCCGAGCTGCATTCAATATCTGCGCA
CGCAACCAAGACGACCACGCCAAAAATATCGGTTTCTTGATGGACAAGCGCGGTGTGTGGACTTTAGCGCCCGCATTTGA
CATGACGTACGCCTACAATCCACAAGGGACATGGACTGGGACGCACCAGATGACGTTCAACGGAAAGCGTAGCGGGTTTA
AGCTAGACGACTTCAAAGCTGTAGCCAAGTTTGCGGGATTGAAGCAAGGACGTTACAAGAAAATTCTTGCTGAAGTTGAA
GACGCCGTAATGCAATGGAAAAAGCTCGCCAAGCAAAACGGAGTGCCGATAAGGATCGCTCGGGCGATTGCCGGAGTACA
TGAATTTATTTTGTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15416.41 Da
• Isoelectric Point: 9.5262

>AT26786 WP_014546447.1 NC_017448:c2630446-2630030 [Fibrobacter succinogenes subsp. succinogenes S85]
MNAYSAQTDESALTLLGKRLAAFRIRNNWTQAQLAEQSGVSKGTVERIERGDSVQVVNFIKVLRACGMLESFLSIFPDDS
PSPMQLLYMGKIKSRQRVRSPHKNTNTANILADNAAEYNADKPANDASKTPWVWNEDK

Nucleotide

• Length: 417 bp

>AT26786 NC_017448:c2630446-2630030 [Fibrobacter succinogenes subsp. succinogenes S85]
ATGAACGCATACTCCGCACAGACTGATGAATCTGCACTCACGCTACTCGGGAAACGTTTGGCAGCATTCCGCATTCGGAA
CAACTGGACACAAGCGCAACTTGCCGAACAGTCGGGAGTGAGCAAGGGAACCGTTGAGCGCATCGAGCGTGGCGATTCTG
TACAGGTTGTAAATTTCATCAAGGTACTACGTGCATGCGGGATGCTTGAAAGCTTTTTAAGCATTTTCCCCGACGATTCG
CCCTCCCCCATGCAGCTTTTATATATGGGAAAAATCAAGAGCCGCCAACGAGTCCGCAGCCCGCATAAAAACACAAACAC
AGCAAACATTTTAGCGGACAACGCCGCCGAATACAACGCAGACAAACCAGCCAACGATGCTTCCAAAACACCCTGGGTTT
GGAACGAAGACAAGTAA

Structures

Toxin

• AlphaFold DB: C9RS34