Detailed information of TA system TA267858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3853351..3855040
• Replicon: chromosome
• Accession: NZ_CP116085
• Organism: Escherichia coli strain DETEC-S566

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: PIC95_RS19190
• Protein ID: WP_000365807.1
• Coordinates: 3853351..3854271 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: PIC95_RS19195
• Protein ID: WP_001295795.1
• Coordinates: 3854258..3855040 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PIC95_RS19150 (3848824)	3848824..3849534	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
PIC95_RS19155 (3849841)	3849841..3850170	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
PIC95_RS19160 (3850182)	3850182..3850348	-	167	Protein_3755	tail fiber assembly protein	-
PIC95_RS19165 (3850419)	3850419..3851033	-	615	WP_001019923.1	YagU family protein	-
PIC95_RS19170 (3851248)	3851248..3851433	-	186	WP_000146240.1	hypothetical protein	-
PIC95_RS19175 (3851482)	3851482..3851640	+	159	Protein_3758	integrase	-
PIC95_RS19180 (3851867)	3851867..3852202	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
PIC95_RS19185 (3852410)	3852410..3853186	+	777	WP_000171155.1	site-specific integrase	-
PIC95_RS19190 (3853351)	3853351..3854271	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PIC95_RS19195 (3854258)	3854258..3855040	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PIC95_RS19200 (3855324)	3855324..3858422	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3811939..3862103	50164

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T267858 WP_000365807.1 NZ_CP116085:c3854271-3853351 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT267858 WP_001295795.1 NZ_CP116085:c3855040-3854258 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0