Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3668863..3669481 Replicon chromosome
Accession NZ_CP116085
Organism Escherichia coli strain DETEC-S566

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC95_RS18325 Protein ID WP_001291435.1
Coordinates 3669263..3669481 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC95_RS18320 Protein ID WP_000344800.1
Coordinates 3668863..3669237 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC95_RS18310 (3663952) 3663952..3665145 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC95_RS18315 (3665168) 3665168..3668317 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
PIC95_RS18320 (3668863) 3668863..3669237 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC95_RS18325 (3669263) 3669263..3669481 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC95_RS18330 (3669654) 3669654..3670205 + 552 WP_000102539.1 maltose O-acetyltransferase -
PIC95_RS18335 (3670321) 3670321..3670791 + 471 WP_000136192.1 YlaC family protein -
PIC95_RS18340 (3670955) 3670955..3672505 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC95_RS18345 (3672547) 3672547..3672900 - 354 WP_000878147.1 DUF1428 family protein -
PIC95_RS18355 (3673279) 3673279..3673590 + 312 WP_000409908.1 MGMT family protein -
PIC95_RS18360 (3673621) 3673621..3674193 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267857 WP_001291435.1 NZ_CP116085:3669263-3669481 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267857 WP_000344800.1 NZ_CP116085:3668863-3669237 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References