Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3436533..3438216 Replicon chromosome
Accession NC_017445
Organism Erwinia sp. Ejp617

Toxin (Protein)


Gene name mosT Uniprot ID E3DHX2
Locus tag EJP617_RS15755 Protein ID WP_012667837.1
Coordinates 3436533..3437450 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID E3DHX3
Locus tag EJP617_RS15760 Protein ID WP_014544491.1
Coordinates 3437443..3438216 (-) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJP617_RS15735 3432343..3433152 - 810 WP_014544488.1 trehalose-phosphatase -
EJP617_RS15740 3433867..3434598 + 732 WP_012667840.1 DUF1275 domain-containing protein -
EJP617_RS15745 3434770..3435189 + 420 WP_012667839.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
EJP617_RS15750 3435192..3436454 + 1263 WP_014544490.1 translesion error-prone DNA polymerase V subunit UmuC -
EJP617_RS15755 3436533..3437450 - 918 WP_012667837.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EJP617_RS15760 3437443..3438216 - 774 WP_014544491.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
EJP617_RS15765 3438701..3439678 - 978 WP_041474535.1 porphobilinogen synthase -
EJP617_RS15770 3439918..3440484 + 567 WP_041474536.1 NAD(P)H-dependent oxidoreductase -
EJP617_RS15775 3440579..3441913 + 1335 WP_041474537.1 cation:proton antiporter -
EJP617_RS18125 3442171..3442531 - 361 Protein_3083 oligosaccharide flippase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34288.50 Da        Isoelectric Point: 4.8381

>T26784 WP_012667837.1 NC_017445:c3437450-3436533 [Erwinia sp. Ejp617]
MDKQSPYYRQVALLLSALPVVAAERCFALKGGTAINLFVRDFPRLSVDIDLAYVLLESRDVALPNVRAALMRIAEILQQQ
AGISAVLQTNHSDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDIVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHQRPLSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGCIPKGKHIQALAKLEAVLAEWIK

Download         Length: 918 bp

>T26784 NC_017445:c3437450-3436533 [Erwinia sp. Ejp617]
ATGGATAAGCAATCACCTTATTATCGGCAAGTTGCGTTGCTGCTCAGCGCATTGCCTGTTGTGGCAGCAGAGCGATGCTT
TGCACTAAAAGGTGGAACGGCCATAAACTTGTTTGTCCGTGATTTTCCACGTTTATCGGTTGATATCGATTTGGCTTATG
TTTTGCTGGAAAGCAGAGATGTGGCATTGCCAAATGTTCGGGCTGCTTTGATGCGTATTGCTGAAATACTGCAACAACAG
GCTGGTATTTCGGCGGTGCTACAAACGAATCATTCTGATGAAATGCGCATTGTGGTTTCTTCTCAGGAGGCACAGATAAA
GATAGAAGTTTCGCCTGTTGCGCGAGGCACACTCTATCCCCCAGAAGAACGTGATATTGTTGAAGCGGTAGAGGACGAGT
TCGGTTTCGCTACTATTCAGGTTGTATCGCTTGCCGATCTCTATGGTGGCAAGCTTTGTGCTGCGCTTGACAGGCAACAT
CCCCGTGATTTTTATGACGTCAAAATGCTACTCGAAACGCAGGGCATTGATCGCCAGATCTTTAATGGTTTCATCACCTA
TCTATTGGGACACCAACGCCCATTATCAGAGGTGCTTAATCCCCGCTGGAAAGATATTTCTGAGCTATATGCGAATGAAT
TTAACGGAATGACATTCGATGCGGTTTCTCTGGAAGAACTCAATGCGATACCCAACTTAATGGTTACTGCTCTCAAAGCA
CAATTCACGCAGCAGGATTATGATTTTTTGATGTCTTTCAAAAGTGGTCAACCGGACTGGAGTCTGGCTCCTGAAGATCA
GATTCAGCATCTACCAGCGGTTAAGTGGAAGTTGCAAAATATTGGGTGCATACCAAAAGGTAAGCATATTCAGGCGTTGG
CGAAGCTTGAGGCTGTTCTTGCCGAGTGGATAAAGTAG

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28905.33 Da        Isoelectric Point: 10.0029

>AT26784 WP_014544491.1 NC_017445:c3438216-3437443 [Erwinia sp. Ejp617]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPQWNDAVLCLQNQLGISVHLAGLT
SLTWQGRSHYLHLTRQTIWLCVEDKTSLPKWFKEFPNVEWLLLSNQKLNMNDEKYLTAVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVTRIDKANIDLGVGKRQIVSGGKLDLK
YQITVPASFVSKGISHG

Download         Length: 774 bp

>AT26784 NC_017445:c3438216-3437443 [Erwinia sp. Ejp617]
ATGTCATCAAAACTAAACTGGCTTTTGCAGAACACTGCGCCTGGCTCCCTGGTATTACAGTCCTGGTTGACAAAAAATGG
TATTAGCCCTTCTTTAGCCAATAAGTATATGCATAGTGACTGGTTACAAAAGCTACGTGCCGGTGTATACGTGCGGAGTG
GGCGTGAACCTCAGTGGAACGATGCCGTCTTATGCTTGCAAAATCAGCTGGGGATTTCTGTGCATCTGGCGGGGCTTACC
AGCCTGACCTGGCAGGGACGCTCTCATTATCTTCACTTAACGCGCCAGACAATTTGGCTTTGCGTAGAAGACAAAACTTC
GTTGCCAAAGTGGTTCAAAGAATTTCCCAATGTCGAGTGGCTTTTACTTTCTAATCAGAAGCTCAATATGAATGACGAAA
AGTATCTGACAGCGGTAGAAATTAAGGGTGAGCGGTTGAAAGCGAGTGTGCCGGAATTAGCGGCTTACGAGATTGCTAAT
GCAGTCCCTGGTTCGCTGTCATTTGAGCACGCTGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCACGTAAAGTCGA
AGTGTTGTTGCAATCCAGTCGAGCAGTGAAAACTAACCGCCTTTACCTGTTTCTGGCCGATCATTATGCTCATGCATGGG
TTACGCGAATAGATAAAGCCAACATTGATTTAGGGGTCGGGAAACGGCAGATCGTATCTGGTGGCAAGCTGGATCTAAAA
TATCAGATCACTGTTCCAGCGAGTTTTGTTAGCAAAGGGATCTCACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3DHX2

Antitoxin

Source ID Structure
AlphaFold DB E3DHX3

References