Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2430..2977 Replicon plasmid pDETEC48
Accession NZ_CP116077
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PIC49_RS25060 Protein ID WP_244493824.1
Coordinates 2699..2977 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6G9U792
Locus tag PIC49_RS25055 Protein ID WP_000079935.1
Coordinates 2430..2699 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS25040 (101) 101..349 + 249 WP_000083839.1 replication regulatory protein RepA -
PIC49_RS25045 (594) 594..668 + 75 WP_001365705.1 RepA leader peptide Tap -
PIC49_RS25050 (661) 661..1518 + 858 WP_016240488.1 incFII family plasmid replication initiator RepA -
PIC49_RS25055 (2430) 2430..2699 + 270 WP_000079935.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PIC49_RS25060 (2699) 2699..2977 + 279 WP_244493824.1 type II toxin-antitoxin system toxin YacB Toxin
PIC49_RS25065 (3023) 3023..3871 + 849 WP_001058003.1 3'-5' exonuclease -
PIC49_RS25070 (3988) 3988..4470 + 483 WP_001311056.1 hypothetical protein -
PIC49_RS25075 (4830) 4830..5946 - 1117 Protein_7 IS91 family transposase -
PIC49_RS25080 (5946) 5946..6311 - 366 WP_000124093.1 hypothetical protein -
PIC49_RS25085 (6839) 6839..7348 + 510 WP_000115002.1 peptide deformylase -
PIC49_RS25090 (7363) 7363..7464 + 102 Protein_10 methionyl-tRNA formyltransferase -
PIC49_RS25095 (7661) 7661..7852 + 192 WP_000175572.1 DUF2164 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..70464 70464
- flank IS/Tn - - 4861..5583 722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10729.37 Da        Isoelectric Point: 8.4615

>T267835 WP_244493824.1 NZ_CP116077:2699-2977 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLAGLPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10198.53 Da        Isoelectric Point: 8.8735

>AT267835 WP_000079935.1 NZ_CP116077:2430-2699 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9U792

References