Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2397..2944 Replicon plasmid pDETEC47
Accession NZ_CP116076
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PIC49_RS24575 Protein ID WP_001384452.1
Coordinates 2666..2944 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag PIC49_RS24570 Protein ID WP_032291093.1
Coordinates 2397..2666 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS24560 (455) 455..1486 + 1032 WP_048257187.1 plasmid replication initiator RepA -
PIC49_RS24565 (2184) 2184..2342 + 159 WP_038349023.1 hypothetical protein -
PIC49_RS24570 (2397) 2397..2666 + 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PIC49_RS24575 (2666) 2666..2944 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PIC49_RS24580 (2984) 2984..3832 + 849 WP_032291092.1 3'-5' exonuclease -
PIC49_RS24585 (4148) 4148..4657 - 510 WP_032291091.1 hypothetical protein -
PIC49_RS24590 (4713) 4713..5315 - 603 WP_000517687.1 ProQ/FINO family protein -
PIC49_RS24595 (5668) 5668..7014 + 1347 WP_063118133.1 protein YagA -
PIC49_RS24600 (7521) 7521..7823 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..87625 87625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T267830 WP_001384452.1 NZ_CP116076:2666-2944 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT267830 WP_032291093.1 NZ_CP116076:2397-2666 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References