Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4258349..4259163 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PIC49_RS20460 Protein ID WP_001054376.1
Coordinates 4258349..4258606 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag PIC49_RS20465 Protein ID WP_001309181.1
Coordinates 4258618..4259163 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS20435 (4253637) 4253637..4254743 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
PIC49_RS20440 (4254808) 4254808..4255788 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PIC49_RS20445 (4255898) 4255898..4256103 + 206 Protein_4001 HNH endonuclease -
PIC49_RS20450 (4256371) 4256371..4257611 - 1241 Protein_4002 helicase YjhR -
PIC49_RS20455 (4257727) 4257727..4257858 + 132 WP_001309182.1 hypothetical protein -
PIC49_RS20460 (4258349) 4258349..4258606 + 258 WP_001054376.1 YjhX family toxin Toxin
PIC49_RS20465 (4258618) 4258618..4259163 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
PIC49_RS20470 (4259219) 4259219..4259965 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PIC49_RS20475 (4260134) 4260134..4260352 + 219 Protein_4007 hypothetical protein -
PIC49_RS20480 (4260390) 4260390..4260506 + 117 Protein_4008 VOC family protein -
PIC49_RS20485 (4260751) 4260751..4261872 + 1122 WP_000010829.1 M42 family metallopeptidase -
PIC49_RS20490 (4261869) 4261869..4262147 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PIC49_RS20495 (4262159) 4262159..4263472 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4250844..4267387 16543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T267828 WP_001054376.1 NZ_CP116074:4258349-4258606 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT267828 WP_001309181.1 NZ_CP116074:4258618-4259163 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References