Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3652663..3653281 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC49_RS17640 Protein ID WP_001291435.1
Coordinates 3653063..3653281 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC49_RS17635 Protein ID WP_000344800.1
Coordinates 3652663..3653037 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS17625 (3647752) 3647752..3648945 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC49_RS17630 (3648968) 3648968..3652117 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIC49_RS17635 (3652663) 3652663..3653037 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC49_RS17640 (3653063) 3653063..3653281 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC49_RS17645 (3653453) 3653453..3654004 + 552 WP_000102559.1 maltose O-acetyltransferase -
PIC49_RS17650 (3654120) 3654120..3654590 + 471 WP_000136192.1 YlaC family protein -
PIC49_RS17655 (3654754) 3654754..3656304 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC49_RS17660 (3656346) 3656346..3656699 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC49_RS17670 (3657078) 3657078..3657389 + 312 WP_000409911.1 MGMT family protein -
PIC49_RS17675 (3657420) 3657420..3657992 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267826 WP_001291435.1 NZ_CP116074:3653063-3653281 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267826 WP_000344800.1 NZ_CP116074:3652663-3653037 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References