267825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3193717..3194422 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag PIC49_RS15455 Protein ID WP_000539521.1
Coordinates 3193717..3194103 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PIC49_RS15460 Protein ID WP_001280945.1
Coordinates 3194093..3194422 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS15435 (3189721) 3189721..3190347 + 627 WP_001295292.1 glutathione S-transferase GstB -
PIC49_RS15440 (3190344) 3190344..3191459 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
PIC49_RS15445 (3191570) 3191570..3191953 - 384 WP_000497137.1 biofilm formation regulator BssR -
PIC49_RS15450 (3192166) 3192166..3193491 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
PIC49_RS15455 (3193717) 3193717..3194103 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIC49_RS15460 (3194093) 3194093..3194422 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
PIC49_RS15465 (3194492) 3194492..3195820 - 1329 WP_000086879.1 GGDEF domain-containing protein -
PIC49_RS15470 (3195828) 3195828..3198176 - 2349 WP_001322378.1 EAL domain-containing protein -
PIC49_RS15475 (3198354) 3198354..3199265 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T267825 WP_000539521.1 NZ_CP116074:3193717-3194103 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT267825 WP_001280945.1 NZ_CP116074:3194093-3194422 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References