Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2599865..2600503 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag PIC49_RS12465 Protein ID WP_000813797.1
Coordinates 2600327..2600503 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC49_RS12460 Protein ID WP_076611057.1
Coordinates 2599865..2600281 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS12440 (2595017) 2595017..2595958 - 942 WP_001251335.1 ABC transporter permease -
PIC49_RS12445 (2595959) 2595959..2596972 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
PIC49_RS12450 (2596990) 2596990..2598135 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
PIC49_RS12455 (2598380) 2598380..2599786 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
PIC49_RS12460 (2599865) 2599865..2600281 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC49_RS12465 (2600327) 2600327..2600503 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC49_RS12470 (2600725) 2600725..2600955 + 231 WP_000494244.1 YncJ family protein -
PIC49_RS12475 (2601047) 2601047..2603008 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC49_RS12480 (2603081) 2603081..2603617 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
PIC49_RS12485 (2603709) 2603709..2604881 + 1173 WP_001236223.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T267823 WP_000813797.1 NZ_CP116074:c2600503-2600327 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT267823 WP_076611057.1 NZ_CP116074:c2600281-2599865 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References