Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2500130..2501718 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PIC49_RS12020 Protein ID WP_001546825.1
Coordinates 2500396..2501718 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PIC49_RS12015 Protein ID WP_001296726.1
Coordinates 2500130..2500396 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS12015 (2500130) 2500130..2500396 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PIC49_RS12020 (2500396) 2500396..2501718 + 1323 WP_001546825.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PIC49_RS12025 (2502116) 2502116..2503015 - 900 WP_001057776.1 LysR family transcriptional regulator -
PIC49_RS12030 (2503155) 2503155..2503463 + 309 WP_001221046.1 hypothetical protein -
PIC49_RS12035 (2503472) 2503472..2504161 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
PIC49_RS12040 (2504235) 2504235..2505182 + 948 WP_000854796.1 aldo/keto reductase -
PIC49_RS12045 (2505285) 2505285..2505440 + 156 WP_001322415.1 hypothetical protein -
PIC49_RS12050 (2505400) 2505400..2505819 + 420 WP_001322416.1 amidohydrolase family protein -
PIC49_RS12055 (2505809) 2505809..2505961 + 153 WP_001322417.1 amidohydrolase family protein -
PIC49_RS12060 (2506112) 2506112..2506684 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49331.00 Da        Isoelectric Point: 8.1369

>T267821 WP_001546825.1 NZ_CP116074:2500396-2501718 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHCRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT267821 WP_001296726.1 NZ_CP116074:2500130-2500396 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References