Detailed information of TA system TA026782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2344084..2344712
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D2T444
• Locus tag: EJP617_RS10670
• Protein ID: WP_004156337.1
• Coordinates: 2344084..2344302 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: EJP617_RS10675
• Protein ID: WP_012668861.1
• Coordinates: 2344332..2344712 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS10645	2340072..2340410	+	339	WP_012668866.1	P-II family nitrogen regulator	-
EJP617_RS10650	2340428..2341729	+	1302	WP_014543632.1	ammonium transporter AmtB	-
EJP617_RS10655	2341804..2342664	-	861	WP_014543633.1	acyl-CoA thioesterase II	-
EJP617_RS10660	2342888..2343445	+	558	WP_012668863.1	YbaY family lipoprotein	-
EJP617_RS10665	2343468..2343785	-	318	WP_014543634.1	MGMT family protein	-
EJP617_RS10670	2344084..2344302	-	219	WP_004156337.1	hemolysin expression modulator Hha	Toxin
EJP617_RS10675	2344332..2344712	-	381	WP_012668861.1	Hha toxicity modulator TomB	Antitoxin
EJP617_RS10680	2344859..2345212	-	354	WP_041474439.1	hypothetical protein	-
EJP617_RS10685	2345670..2345816	-	147	WP_004156349.1	type B 50S ribosomal protein L36	-
EJP617_RS10690	2345827..2346087	-	261	WP_014543637.1	type B 50S ribosomal protein L31	-
EJP617_RS10695	2346241..2349381	-	3141	WP_014543638.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8627.06 Da
• Isoelectric Point: 8.9007

>T26782 WP_004156337.1 NC_017445:c2344302-2344084 [Erwinia sp. Ejp617]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Nucleotide

• Length: 219 bp

>T26782 NC_017445:c2344302-2344084 [Erwinia sp. Ejp617]
ATGACTGACAAACTTCTTACGAAAACTGACTACCTGATGCGCCTCAGACGTTGTCGTTCAATCGACACCTTGGAACGCGT
GATTGAAAAGAACAAGTATGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCCGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTTGCCGTCTGGAAGTTTGTCCGTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14721.47 Da
• Isoelectric Point: 4.8834

>AT26782 WP_012668861.1 NC_017445:c2344712-2344332 [Erwinia sp. Ejp617]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDCDLISQIDEYL
DDTFMLFSNYGVNTHDLQRWQKSAKRLFNIFAKECLMSQVQSSHSF

Nucleotide

• Length: 381 bp

>AT26782 NC_017445:c2344712-2344332 [Erwinia sp. Ejp617]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCACCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTACAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACTGCGATTTGATAAGTCAGATTGATGAGTATCTG
GACGACACCTTTATGCTCTTCAGCAATTATGGCGTCAACACTCATGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCCTAATGAGCCAGGTTCAATCCAGCCATTCATTTTAG

Structures

Toxin

• AlphaFold DB: A0A831EPQ0