Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 966146..966800 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name cptA Uniprot ID B7N7E0
Locus tag PIC49_RS04750 Protein ID WP_000244769.1
Coordinates 966393..966800 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC49_RS04745 Protein ID WP_000354046.1
Coordinates 966146..966412 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS04725 (962234) 962234..963667 - 1434 WP_022646090.1 6-phospho-beta-glucosidase BglA -
PIC49_RS04730 (963712) 963712..964023 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
PIC49_RS04735 (964187) 964187..964846 + 660 WP_000250269.1 hemolysin III family protein -
PIC49_RS04740 (964923) 964923..965903 - 981 WP_000886049.1 tRNA-modifying protein YgfZ -
PIC49_RS04745 (966146) 966146..966412 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC49_RS04750 (966393) 966393..966800 + 408 WP_000244769.1 protein YgfX Toxin
PIC49_RS04755 (966840) 966840..967361 - 522 WP_001055874.1 flavodoxin FldB -
PIC49_RS04760 (967473) 967473..968369 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
PIC49_RS04765 (968394) 968394..969104 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC49_RS04770 (969110) 969110..970843 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16062.03 Da        Isoelectric Point: 11.5554

>T267815 WP_000244769.1 NZ_CP116074:966393-966800 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGK
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267815 WP_000354046.1 NZ_CP116074:966146-966412 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J3T1

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References